Weekend Road Trip: Dr. Denene Lofland Featured at International Conference

This weekend, more than 10,000 of the world’s top scientists, physicians, researchers, and health care professionals are gathering in San Francisco at the 49th Interscience Conference on Antimicrobial Agents and Chemotherapthy (ICAAC). The purpose of this meeting of the great minds is to foster solutions to the problems associated with infectious disease. Each year, by invitation only, a handful of renowned scientists are selected to present their work, ideas, and new discoveries to their peers.

I’m pleased to announce that Dr. Denene Lofland’s abstract on preclinical microbiological, efficacy, and pharmacological evaluations of a novel chemical entity (new potential antibiotics) was selected for an oral presentation at the San Francisco conference. Denene also had three other abstracts accepted by the ICAAC committee. The oral presentation is listed on ICAAC’s website as:

F1-1219. Oral Antibacterial Activity of a Novel Pentacycline
D. LOFLAND, W. O’BRIEN, X. XIAO, D. HUNT, R. CLARK, L. PLAMONDON;
Tetraphase Pharmaceuticals, Watertown, MA.

Shown below is the chemical structure of a pentacycline, an antibacterial. It shows activity against common bacterial pathogens (like MRSA and E. coli).

Tetraphase image

This is Denene’s 14th ICAAC accepted abstract. She has also authored or co-authored 10 peer-reviewed journal articles, such as:

– In Vitro Antibacterial Activity of the Peptide Deformylase Inhibitor BB-83698

– DNA Binding Ligands With Improved In Vitro and In Vivo Potency Against Drug-resistant Staphylococcus Aureus